Chunk #8 — Background — Genetic model

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Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

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4. The presence of subclinical markers or "endophenotypes" that can be seen as a partially penetrant form of the disease. (In this simulation, the endophenotypes can be viewed as a manifestation of a partial disease genotype, e.g., only one of two genes required for trait expression.)