To select transcripts that would reflect effects of drug use irrespective of which specific drug(s) were used, only transcripts that by GAP criteria were significantly changed in the majority (30/34) of Group I–II drug abuse cases and in two of the three drug-defined groups (COC+, THC+, and PCP+) were included. After exclusion of cDNA clones removed from GenBank, the list contained 139 transcripts, which were sorted according to function and location ( Table S2 ). Three functional groups, comprising 39 transcripts ( Table 3 ), are discussed below.