Chunk #34 — Online Methods — Stratified LD score regression

Source

Partitioning heritability by functional annotation using genome-wide association summary statistics.

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yes

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We model β as a mean-zero random vector with independent entries. We have C functional categories C1, …, CC, and we allow the variance of βj —i.e., the per-SNP heritability at SNP j—to depend on these functional categories that we include in our model via the equation