Chunk #28 — Results — Overlap of ASD and schizophrenia GWAS

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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

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Given these observations regarding ASD and schizophrenia, and to further identify novel loci, we meta-analysed the PGC schizophrenia and PGC ASD GWAS data (see Additional file 1: Figure S12 for Manhattan and PP plot). After removing significant loci (+/−1 Mb) previously reported in the PGC schizophrenia analyses, we observed 12 new GWS loci (see Table 3; Additional file 14 and Additional file 15).Table 3Novel GWS loci from combined ASD-schizophrenia GWASSNPLocus rangeA1Odds ratio (95% CI) P valueGenes within locusASDSCZCombinedrs57709857chr8:38014429..38316849A0.92 (0.86–0.97)0.93 (0.91–0.96)0.93 (0.91–0.95)4.2 × 10−9 BAG4 DDHD2 FGFR1 LETM2 LSM1 PLPP5 WHSC1L1rs1353545chr3:60276185..60305117C1.05 (1.00–1.10)1.06 (1.04–1.09)1.06 (1.04–1.08)1.1 × 10−8 FHITrs6803008chr3:71433554..71679148T0.94 (0.90–0.99)0.95 (0.93–0.97)0.94 (0.93–0.96)1.3 × 10−8 FOXP1 MIR1284rs2828478chr21:25092482..25219939A1.07 (1.02–1.12)1.06 (1.04–1.08)1.06 (1.04–1.08)1.6 × 10−8 Noners9879311chr3:10317432..10520739T1.08 (1.03–1.13)1.05 (1.03–1.08)1.06 (1.04–1.08)1.9 × 10−8 ATP2B2 GHRL GHRLOS LINC00852 MIR378B MIR885 SEC13 TATDN2rs73416724chr6:43234901..43411659A1.11 (1.03–1.20)1.09 (1.05–1.13)1.09 (1.06–1.13)3.0 × 10−8 ABCC10 CRIP3 MIR6780B SLC22A7 TTBK1 ZNF318rs61847307chr10:53935082..54035437T0.95 (0.90–1.00)0.94 (0.92–0.96)0.94 (0.92–0.96)3.1 × 10−8 PRKG1rs7122181chr11:81178475..81209569A0.95 (0.91–1.00)0.95 (0.93–0.97)0.95 (0.93–0.97)3.7 × 10−8 Noners880446chr20:62113220..62178105A1.07 (1.02–1.13)1.06 (1.04–1.09)1.06 (1.04–1.09)4.4 × 10−8 EEF1A2 PPDPF PTK6 SRMSrs7521492chr1:163581663..163790947A1.05 (1.00–1.10)1.06 (1.03–1.08)1.06 (1.04–1.08)4.7 × 10−8 Noners72986630chr19:11849736..11943697T1.07 (0.95–1.21)1.16 (1.10–1.22)1.14 (1.09–1.20)4.7 × 10−8 ZNF440 ZNF441 ZNF491 ZNF823rs4904167chr14:84628384..84701798T1.08 (1.03–1.14)1.05 (1.03–1.07)1.06 (1.04–1.08)4.9 × 10−8 None