The multi-level approach we used in this study enabled us to evaluate a central brain region proposed to be involved in ADHD pathophysiology and also to identify how the atypical functioning of this region in individuals with ADHD may be related to a core, but component, behavioral dysfunction. Because reward discounting is a trans-diagnostic phenotype (related to ADHD but not specifically so), these results can inform ADHD as well as the relation of ADHD to other psychopathologies that also involve reward processes as one of their components.