Demographic data were recorded by the first author. All study and sample characteristics for the PAE and COA literature are provided in Tables S1 and S2, respectively. In summary, studies from the PAE domain compared children with prenatal alcohol exposure (defined in Table S1 for each study, when available) to children without evidence (either physical or from parental reports) of prenatal alcohol exposure as the control group. If an exposed group was not defined by the authors, we conservatively assigned individuals with any PAE to the exposed group, due to varied differences in details and thresholds regarding maternal alcohol consumption during pregnancy. Conversely, if the non-exposed group was not defined by the authors, we included individuals with no or unknown alcohol exposure. Studies from the COA domain compared children of an alcohol dependent parent to children without an alcohol dependent parent as the control group. Table S3 contains a list of all instrument abbreviations with the detailed names of each instrument. Two-sample t-tests were used to test for differences in quantitative demographic characteristics and chi-squared tests were used to compare categorical differences between the PAE and COA domains of literature.
