SORL1 (P=1.8×10−7), and FERMT2 (P=1.0×10−5). The direction of effects were concordant with the previous IGAP GWAS logistic regression analysis for AD risk1 at all suggestive loci: AD risk-increasing alleles were all associated with a hazard ratio above 1 and earlier AAO, whereas AD risk-decreasing alleles were all associated with a hazard ratio below 1 and later AAO (Table 1b, Supplementary Table 2). We also identified 14 novel loci that reached suggestive significance in the survival analysis, 3 of which (rs116341973, rs1625716, and rs11074412) were nominally associated with AD risk (Bonferroni-corrected threshold: P=0.05/22=2.27×10−3) in the IGAP GWAS (Table 1b, Supplementary Fig. 2, 3).
