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Chunk #31 — Discussion

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Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.
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self-administration (Zimmermann et al., 2009). However, the nature of these associations differed based on measurement scales: when considering a baseline measure of alcohol sensitivity, participants who reported needing more drinks to achieve stimulant effects showed significantly higher self-administration. During self-administration, however, self-reported sedation appeared to be a more robust predictor of self-administration. These findings are not intuitive but may reflect complexities in studying alcohol sensitivity constructs, in part due to variability in measurement approaches (King et al., 2011b; Morean and Corbin, 2010).