The current study extends these prior results by examining the 20 year course after the onset of an AUDs in probands who met criteria for an AUD at ~age 30 (by definition no subject had an AUD at baseline at about age 20). The goals of these analyses were to: (1) examine rates of both initial and sustained remission from AUDs over a 20+ year period; and (2) evaluate premorbid characteristics and other risk factors that predicted AUD remission over time. We hypothesized that genetically-influenced risk factors for AUD onset, including a low LR to alcohol and a FH of AUDs, would also predict whether a person remitted from an AUD.