With a combined map of microsatellite and SNP markers the dataset was reanalyzed, as described in the original linkage study (Schuckit et al., 2005; Wilhelmsen et al., 2003), using SOLAR. When divided into the two stages of sample sets from the previous study, significant linkage was found in stage 1 samples with a peak LOD score of 3.14; however, when combining the initial 139 sibling pairs with the additional 99 sibling pairs in stage 2, the linkage signal lowered to a peak LOD score of 1.61. The LOD score plot can be seen in Figure 2.
