Chunk #45 — Methods — SNP-based h2 and partitioning heritability enrichment.

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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.

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We used LDSC [12] to estimate the SNP-based h2 for common SNPs mapped to HapMap3 [54], with Europeans from the 1000 Genomes Project [46] as the LD reference panel. We excluded the major histocompatibility complex (MHC) region (chr6: 26–34Mb).