Power for Common versus Rare alleles.Plots of power (solid lines) and coverage (dotted line) for increasing sample sizes of cases and controls (x-axis). From left to right plots are given for increasing effect sizes (relative risk per allele). Both power and coverage range from 0 to 1 and are given on the y-axis. Results are for single-marker test of association. The top two rows show the power for rare risk alleles (RAF<0.1) and the bottom two rows show the power for common risk alleles (RAF>0.1). Rows 1 and 3 show power for case-control studies simulated in a Caucasian population based on the CEU HapMap panel. Rows 2 and 4 relate to case-control studies simulated from the YRI HapMap panel.
