Alcohol initiation was significantly associated with increased hazards of subsequent onsets of INT and EXT (HR⩾1.44, p ⩽ 2.10×10−4, pFDR ⩽ 1.68×10−3), except for panic, social anxiety, and oppositional defiant disorder symptoms (HR⩽1.45, p ⩾ 0.047, pFDR ⩾ 0.147). Neither alcohol intoxication nor AUD symptom(s) was significantly associated with risk for any subsequent symptom onsets (0.42⩽HR⩽1.54, p ⩾ 0.031, pFDR ⩾ 0.12). AUD diagnosis was associated with increased hazards of a subsequent major depressive episode and suicidal ideation (HR⩾1.38, p ⩽ 5.10×10−3, pFDR = 0.024) but no other outcomes (HR = 0.81–1.38, p ⩾ 0.20; Figure 2; online Supplementary Table S5).
