To date, few studies have included both LR and impulsivity in the same prospective model to evaluate how these endophenotypes operate when considered together. We published one such evaluation of men most of whom were college graduates, but the sample was modest in size (N=393) and the model was structured such that some potential mediators were measured at the same time as the outcome (Schuckit and Smith, 2006). However, in that model the family history of AUDs related to both a low LR and to an externalizing construct that reflected higher levels of impulsivity and sensation seeking, and there was only a weak relationship between that externalizing variable and LR. That SEM demonstrated potential mediation of the relationship of both LR and the externalizing variable to adverse alcohol outcomes through positive alcohol expectancies and drinking to cope.
