Chunk #12 — INTRODUCTION — Comparison with other genome editing technologies — • Editing efficiency

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Genome engineering using the CRISPR-Cas9 system.

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SpCas9 and TALENs have both been shown to facilitate efficient genome editing in a variety of cell types and organisms. However, owing to the ease of targeting, Cas9 can be used to target multiple genomic loci simultaneously, by co-delivering a combination of sgRNAs to the cells of interest.