Previously, we carried out a schizophrenia GWA study, SGENE-plus, followed by meta-analysis of the top 1500 results with data from the International Schizophrenia Consortium (ISC) and the Molecular Genetics of Schizophrenia (MGS) group15. Loci having P values less than 1 × 10−4 (covered by 39 SNPs located in 33 genomic regions) were followed up in a data set of up to 10,260 schizophrenia cases and 23,500 controls14. In this work , we broaden our phenotype of interest to psychosis (schizophrenia, bipolar disorder and related psychoses), examining the same group of follow-up SNPs in a data set augmented by 7,469 bipolar disorder cases, 1,535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46,160 controls.
