Genetic correlations were also calculated using the sex-specific GWAS summary statistics (Supplementary Figures 14 and 15). Male alcohol consumption showed a negative genetic correlation with childhood height (rG=−0.23, s.e.=0.07, P=0.002), childhood obesity (rG=−0.26, s.e.=0.08, P=0.001) and infant head circumference (rG=−0.34, s.e.=0.11, P=0.002). Female alcohol consumption was genetically correlated with college completion (rG=0.3, s.e.=0.06, P=1.4 × 10−7), height (rG=0.18, s.e.=0.04, P=2.4 × 10−5) and bipolar disorder (rG=0.22, s.e.=0.08, P=0.005). Several metabolic traits were found to have negative genetic correlations with female alcohol consumption including low-density lipoprotein cholesterol (rG=−0.23, s.e.=0.07, P=9 × 10−4) and leptin (rG=−0.41, s.e.=0.11, P=3 × 10−4).
