Chunk #11 — METHODS — Measures — Family History of Smoking

Source

Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.

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Family histories of smoking were available for 99% of the cohort. The family history consisted of reports of smoking history provided by study members and both parents for study members’ siblings, parents, and grandparents. The family history was summarized as the proportion of family members in the pedigree who were ever regular smokers, adjusted to account for differences in genetic relatedness to the proband of first- and second-degree relatives.40