Given a set of GWAS data or a SNP list, GWAS3D can detect the variants’ regulatory effects such as the assigned population haplotype, the experimentally derived genetic/epigenetic signals, the predicted change of transcription factor binding affinity on different alleles and sequence conservation in a particular cell type. The server further calculates the combined effect of each variant and prioritizes them based on the probability of affecting gene regulation. The overall workflow of GWAS3D is shown in Figure 1.
