Data from the Rush Memory and Aging Project has generated more than 125 peer-reviewed publications to date on a wide range of issues related to aging and AD. The main find ings can be summarized into four major headings: 1) evidence of common causation of loss of cognitive, motor and olfactory function; 2) continuum of cognition and neuropathology from normality to MCI to dementia; 3) implications of mixed pathologies; 4) evidence of neural reserve.