adolescents than adults (He & Crews, 2007). Imaging studies have shown that adolescents with alcohol use disorders have smaller hippocampi (De Bellis et al., 2000; Nagel, Schweinsburg, Phan, & Tapert, 2005) and that the effect of alcohol on hippocampal volume is greater in adolescents than in adults (Geil et al., 2014; Jacobus & Tapert, 2013). Ethanol-induced reductions in hippocampal volume are due in part to inhibition of neurogenesis by alcohol (Morris, Eaves, Smith, & Nixon, 2010), particularly at the higher concentrations of alcohol experienced during alcohol binge exposure (Crews, Mdzinarishvili, Kim, He, & Nixon, 2006).
