A subset of our parents and children (n=452 individuals) were genotyped using the Illumina Infinium Human-Hap300 duo chip (Illumina, Inc., San Diego, California, USA). As described in detail below, individuals (n=204) who were ascertained after the initial genome screen were genotyped using TaqMan ‘Assays-on-Demand’ or ‘Assays-by Design’ products (Applied Biosystems, Foster City, California, USA).
