(2) Linkage Disequilibrium (LD): users can input the two-locus LD (r2) between the SNP marker and the hypothesized causal variant. When the LD between the genotyped and "causative" marker is r2, the sample size is increased by 1/r2, because in order to have the same power to detect a causative variant when using a marker that is r2 away, an increase in sample size of 1/r2 is required [7,8].
