In conclusion, similar to recent results from molecular genetic studies1, we have found compelling evidence that schizophrenia and bipolar disorder partially share common genetic etiologies, which challenges the nosological dichotomy between schizophrenia and bipolar disorder. These results should inform the diagnostic classification used in linkage and association studies and encourage further search for endophentypic traits shared between the two disorders. Within clinical practice, the underlying structure of psychosis and knowledge of their common etiology might be beneficial for treatment considerations and development of psychosis medication.
