input data. Additional analyses (not shown) indicate that most of the signal was derived from SNPs with allele frequencies > 0.1; low-frequency imputed SNPs were not generally inferred to be associated with schizophrenia. Figure 3 compares ABPA estimates of the genetic architecture of schizophrenia and four biomedical diseases. 66 There are similarities across the estimates for these complex traits as all are relatively highly polygenic, and common SNPs explain substantial proportions of variation. However, these results suggest that the genetic architecture of schizophrenia is left-shifted with greater numbers of SNPs with smaller effects.
