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Chunk #43 — Understanding MEA signals — What do microelectrodes detect?

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Revealing neuronal function through microelectrode array recordings.
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A microelectrode can detect the changes in the extracellular field caused by the current flows from all ionic processes across the morphology of the closest neuron and from other nearby cells, not only neurons (Buzsáki et al., 2012; Anastassiou et al., 2013). The effect of the transmembrane currents on the electric field and the detected potential on a microelectrode depend on the magnitude, sign, and the distance from the recording site (Nunez and Srinivasan, 2006), see Section The extracellular space.