We tested two hypotheses related to the incorporation of functional genomic information to understand genetic and G ×E effects on alcohol use outcomes. We found that DHS-scores were more parsimonious compared to the GW-scores while capturing the majority of the same signal. The per-SNP effects for variants in the DHS-scores were 1.1 to 1.4 times larger than the per-SNP effect for variants in the GW-scores. We found a similar pattern of effects for a second non-psychiatric phenotype, height. We also found that DHS SNPs were modestly enriched for G×E effects compared to non-DHS SNPs in a model looking at romantic relationship status as the moderator.
