TATES p-value PT equals the smallest weighted p-value, with the null-hypothesis that none of the phenotypes is associated with the GV, and the alternative hypothesis that at least one of the phenotypes is associated with the GV. The TATES procedure is implemented in a Fortran 77 program and an R script, both of which are freely available from the website (http://ctglab.nl/software). The Fortran program takes less than 1 minute to calculate the TATES trait-based p-values PT for 12 phenotypes and 437,598 GVs on an ordinary desktop computer with Intel(R) Core(TM)2 Duo CPU 2.99 GHz, RAM 2.94 GB, and 32-bit Windows XP Professional Version 2002.
