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Chunk #15 — Results — Genome-Wide Correlations between Psychiatric and Immune-Inflammatory Phenotypes

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Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.
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p = 4.0×10−4), CD (rg = 0.21 ± 0.05, p = 3.7×10−5), psoriasis (rg = 0.25 ± 0.08, p = 3.8×10−3), and UC (rg = 0.23 ± 0.06, p = 2.0×10−4). Major depressive disorder was positively correlated with hypothyroidism (0.33 ± 0.09, p = 5.0×10−4). Similarly, neuroticism was positively correlated with hypothyroidism (rg = 0.25 ± 0.06, p = 7.2×10−5), in addition to childhood ear infection (rg = 0.13 ± 0.04, p = 8.0×10−4). OCD was negatively correlated with type 1 diabetes (rg = −0.32 ± 0.11, p = 5.4×10−3). Smoking behavior was positively correlated with CRP (rg = 0.31 ± 0.07, p = 3.6×10−5) and with rheumatoid arthritis (rg = 0.17 ± 0.05, p = 2.3×10−3). SZ showed positive genetic correlations with CD (rg = 0.12 ± 0.03, p = 2.0×10−4), PBC (rg = 0.14 ± 0.05, p = 2.0 × 10−3), SLE (rg = 0.15 ± 0.04, p = 2.0×10−4), and UC (rg = 0.14 ± 0.04, p = 2.0×10−4). Finally, we observed a positive genetic correlation between Tourette syndrome and allergy (rg = 0.24 ± 0.06, uncorrected p = 2.7×10−5). Additionally, several large-magnitude correlations attained a nominal threshold of statistical significance (e.g., autism-allergy and OCD-celiac); these correlations