African American (AA) populations may be particularly interested in the benefits of genetic information and genetic testing [Lemke et al., 2012; Michie et al., 2011; O'Daniel and Haga, 2011; Singer et al., 2004]. Yet, AAs perhaps face a large number of potential barriers to accessing ES/WGS and benefiting results. Genetic knowledge among some AAs is limited [Akinleye et al., 2011; Goldenberg et al., 2011; Kessler et al., 2007; Suther and Kiros, 2009] and misperceptions of genetic risk, differences in the cultural acceptability of genetic services, and distrust [Eichmeyer et al., 2005] adversely impact test utilization [Susswein et al., 2008] and contribute to underrepresentation of AAs in genetic research. Furthermore, the informativeness of genetic results may differ for AA populations because AAs are more likely to have variants of uncertain significance [Nanda et al., 2005; Tennessen et al., 2012].
