In both populations, the age-adjusted mean AUDIT-C scores (0 vs. 8+) were more strongly associated with the absence of the ADH1B minor allele than were AUD diagnostic codes: aOR = 0.59 vs. 0.86 in AAs and 0.48 vs. 0.68 in EAs. Because these effects were independent, combining an AUDIT-C score of 8+ with an AUD diagnosis compared to an AUDIT-C of 0 and no AUD yielded an aOR of 0.51 for AAs and 0.33 for EAs. When both AUDIT-C and AUD data are available, determining whether the added complexity of using both measures is justified will depend on the intended application.
