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Chunk #1 — Introduction

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Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.
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Estimation of people’s absolute risk of coronary heart disease, based on the Framingham, PROCAM, and QRISK equations,3 4 5 has become established as a means of targeting preventive interventions to those at highest risk. Earlier risk functions for estimating the risk of type 2 diabetes required an oral glucose tolerance test, which is impractical for screening large numbers of people. Despite evidence that some interventions prevent or delay development of type 2 diabetes in people at high risk,6 the prediction of risk of new onset type 2 diabetes has not been part of routine clinical practice.