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Chunk #28 — METHODS — hiPSC differentiation to NPCs and neurons

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Modelling schizophrenia using human induced pluripotent stem cells.
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Antipsychotic drugs were added for the final three weeks of a three-month differentiation on astrocytes and for the final two weeks of a six-week differentiation on PORN/laminin alone. Drugs were resuspended in DMSO at the following concentrations: Clozapine (5 µM), Loxapine (10 µM), Olanzapine (1 µM), Risperidone (10 µM) and Thioridazine (5 µM).