Chunk #24 — RESULTS — Heritability and Polygenic Risk Score Analyses

Source

Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.

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Tourette syndrome SNP-based heritability (h2g) was estimated in the primary GWAS meta-analysis using LDSC (h2g=0.21, SE=0.024, p<2.0×10−16). Pairwise genetic correlations across the three independent case-control datasets (GWAS1, GWAS2, TIC) confirmed a significant, shared polygenic architecture (rgGWAS1-GWAS2=0.86 (SE=0.21), p=3.9×10−5; rgGWAS1-TIC=0.84 (SE=0.30), p=4.5×10−3; rgGWAS2-TIC=0.93 (SE=0.26), p=4×10−4).