We next examined the possible pathways through which parental externalizing polygenic scores may be associated with adolescent externalizing behavior, controlling for adolescent externalizing polygenic scores. Covariates included adolescent age and sex. We conducted mediation analyses using the mediation package (Tingley et al., 2020) for R (R Development Core Team, 2019) with clustered standard errors at the family level. These mediation analyses tested the extent to which the association between parental externalizing polygenic score and adolescent externalizing behavior is explained by parental externalizing psychopathology and parenting measures (i.e., parental involvement, parent-child communication, parent-child closeness, and parental knowledge). Each potential mediator was tested in a separate model. Confidence intervals for indirect effects were calculated via the bootstrap method based on 5000 replications.
