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Chunk #9 — INTRODUCTION

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Estimation of significance thresholds for genomewide association scans.
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facilitates the comparison of results between different marker panels as well as those obtained by imputation methods that estimate the genotypes of markers not directly typed [Marchini et al., 2007]. However, permutation methods for multiple test correction only take account of the genotyped markers, and use of these methods with standard thresholds may, potentially, lead to over–optimistic interpretation of significant results.