paperKB
coga / coga-kb
Help
Sign in

Chunk #49 — Online Methods — Variant Filters — Panel of Normals

Source
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.
Embedded
yes

Text

The more normal samples used to construct this panel, the higher the power will be to detect and remove rare artifacts. Therefore, we typically we use all the normal samples readily available. The results presented here were obtained by using a panel of whole genome sequencing data from blood normals of 125 solid tumor cancer patients. The samples used as part of the virtual tumor approach were not included in this panel.