be higher using methods that leverage the fact that multiple tissues are collected and analyzed for each donor. Since the underlying parameters are merely rough estimates, we repeated the power analysis with different values (10 to 20 SNPs, 20,000–100,000 transcripts) and show that 80% power is achieved for MAF between 3 and 4% for cis-eQTLs. For trans-eQTLs, this range in transcripts results powered MAFs between 4 and 5% (Supplementary Figure 5).
