We found that maternal pre-pregnancy diabetes and pregnancy-related hypertensive disorder were associated with early menarche. Two studies reported no association between prenatal exposure to maternal preeclampsia and age at menarche.54,55 However, a large UK cohort study found an earlier mean age at menarche in daughters whose mothers had preeclampsia during their gestation.12 Prenatal exposure to maternal diabetes has been previously reported to be associated with childhood obesity,29-31 but we are the first to investigate associations with early menarche in daughters.
