in which the functional consequence of the risk allele was unclear. However, the new Alzheimer’s disease genes are even more interesting, and 8 of these associations are found in loci that harbored only suggestive evidence of association in the IGAP study. These genes include AP2A1, AP2A2, FUS, MAP1B, TBC1D7 and others that are now significant at a threshold adjusted for genome-wide testing. This analysis therefore helps to prioritize the long list of suggestive IGAP associations (Figs. 5a; Supplementary Figs. 9–17). Interestingly, both AP2A1 and MAP1B were recently identified as hub proteins in Alzheimer’s disease proteome networks and had lower protein expression levels in Alzheimer’s disease brains compared to ALS, PD, or control brains38.
