The highest multipoint LOD of 2.7 (p = 0.0002) was found on chromosome 5 using the dataset maximising data collected at a younger age, and with lightest drinkers dropped. A similar LOD (2.6) was found when maximising data collected at an older age. However, including light drinkers reduced maximum LOD scores in the region to 1.2 and 1.0 respectively for the younger and older samples. While none of these findings are significant by standard criteria for linkage studies, those LOD scores ≥2.2 could be considered suggestive based on an expectation of statistical evidence occurring one time at random in a genome scan (a pointwise significance level of 7 × 10−4 for sib-pair studies), as proposed by Lander and Kruglyak (1995).
