As previously reported2,3, we found the average observed RAs across traits and diseases to decrease monotonically with increasing FST from EUR ancestry. More specifically, the mean observed RA across traits and diseases is 72%, 64% and 24% in participants of SAS, EAS and AFR ancestry, respectively. Consistently, the number of traits and diseases for which the reduction of RA was statistically significant (Wald test, p-value <0.05) also differed between ancestries (Supplementary Table 2). In SAS ancestry for example, the reduction of RA was significant only for height, BMI, LDL and HDL. However, in EAS ancestry the reduced RA of TG and Asthma PGS was also significant, while PGSs of all traits had significantly reduced RA in AFR ancestry.
