mice – including recombinant inbred mice,276, 277 the hybrid mouse diversity panel278 and the diversity outcross279 – are now available for identifying the genetic and genomic factors that may be unique to, or shared between, measures of impulsivity that each predict susceptibility for drug self-administration and addiction-related behaviors. Because of the advent of highly sophisticated genetics resources that can uncover biological influences never before considered, it is crucial that the relationship between dimensions of impulsivity and addictions be dissected at the behavioral and neural circuitry level. By doing so, we may make progress towards understanding the concept of susceptibility for addictions at all levels of analysis – from genes to cells to circuits to behavior.
