Chunk #30 — Results — Identification of SE contributing to AUD susceptibility

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RNA alternative splicing impacts the risk for alcohol use disorder.

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Of the 1093 SE, we found that five were significantly associated with DSM-IV dependence (Fig. 2B) and 24 were significantly associated with SXCT (Fig. 2C); two events were associated with both DSM-IV and SXCT. Overall, the result of our MR-based analysis indicated that 27 SE events contributed to at least one of these AUD traits (Supplementary Table S1).