The internalizing model in Figure 1 describes a pathway of risk that is likely most evident in those children who eventually form a Negative Affect SUDs. However, the processes underlying this pathway are not necessarily restricted to children with this outcome. Rather, we posit that this is a more general risk process that varies in the extent to which it contributes to risk for any form of SUD across individuals. Thus, the emphasis of this model is on the risk mechanism rather than on the specific SUD outcome.