In a large survey of the United States general population, perceived alcohol stigma among people with DSM-5 AUD appeared to be significantly elevated among specific psychiatric comorbidity profiles that were empirically derived using latent class analysis. Respondents with AUD who had internalizing psychiatric comorbidity, as compared to those with no psychiatric comorbidity or externalizing comorbidity, had significantly higher levels of perceived alcohol stigma. Longitudinal research is needed to understand the causes and consequences of elevated perceived alcohol stigma among people with AUD and internalizing psychiatric comorbidity.