critical anatomical link between the PFC and HC (Vertes et al. 2015). Thus, we hypothesized that nRE plays a specific role in 2–5 Hz PFC-to-HC synchronization, whereas theta coupling may use the direct HC-to-PFC projection. In this study, we recorded local field potential oscillations in the PFC, HC, and nRE in the urethane-anesthetized rat, while stimulating RPO, and demonstrated that removal of nRE influence, either statistically (using partial correlations) or experimentally (by pharmacologic inactivation), resulted in decreased coherence between the PFC and hippocampal 2–5-Hz oscillations, but had minimal effect on theta coupling.
