The results of our study should be interpreted in view of its strength and limitations. Important strengths of this study include the analyses of the largest population sample to date which has led to a substantial increase in power to identify genetic variants associated with lifetime cannabis use. The association analyses were complemented with several follow-up analyses to further investigate the genetic basis of cannabis use and the extent to which the genetic aetiology of cannabis use overlaps with that of other complex phenotypes. Strong genetic correlations across a wide spectrum of traits are observed, confirming that lifetime cannabis use is a relevant measure of an individual’s vulnerability.
