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Chunk #16 — MATERIALS AND METHODS — Tag SNP Selection and Genotyping

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Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD).
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et al., 2008), including DRD1–5, SLC18A2, SLC6A3, DDC, TH, and COMT. Several coding SNPs were genotyped, such as rs155417 and rs5326 in DRD1, rs6279 in DRD2, rs6347 in SLC6A3, rs11575542 and rs11575377 in DDC, and the well-studied nonsynonymous SNP rs4680 in COMT. The well-known TaqIA polymorphism in DRD2 was not included because, as noted previously, it is actually located in a different gene.