accumbens and caudate nucleus bilaterally during reward anticipation, as well as left putamen and right inferior and medial frontal gyrus, superior frontal gyrus bilaterally and left cingulate gyrus. Cannabis users showed enhanced reward anticipation activity in the middle temporal gyrus bilaterally, right cuneus and right parahippocampal gyrus. When compared to tobacco-smoking controls, cannabis users also showed reduced anticipation activity in the same areas, with the exception of the nucleus accumbens bilaterally, the right medial frontal gyrus and the left cingulated gyrus, indicating that anticipation activity in these regions may be attenuated by both cannabis and nicotine [176]. In accordance with Nestor et al. (2010) [175], response to contrasted outcome notification was associated with greater activity in the putamen bilaterally and the right caudate nucleus compared with non-smoking controls [176]. The putamen was more activated in cannabis users than in non-smokers and tobacco-smoking controls, indicating that changes in this area were mainly due to cannabis use [176].
